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[Lecture] Decoding Regulatory Mechanisms of Hematopoiesis

DEC . 27 2018
Title: Decoding Regulatory Mechanisms of Hematopoiesis

Time: 13:00-14:00, Dec. 27, 2018, Thursday


Venue: Room 411, Jinguang Life Sciences Building, Peking University


Speaker: Xin Liu, Ph.D.


Abstract: Hematopoiesis requires highly coordinated gene expression through transcriptional and post-transcriptional mechanisms. By comparing enhancer landscape, transcriptional factor occupancy, 3D chromatin structure and transcriptomic changes during blood cell differentiation, I identified lineage-specific enhancers and macro-molecular interactions driving enhancer activation, providing initial insights into enhancer dynamics and gene expression programs directing lineage-specific transcription during hematopoiesis. Further comparison between the proteomic and transcriptomic changes in erythroid development uncovered post-transcriptional pathways leading to enhanced mitochondrial biogenesis. Perturbation of mitochondria interrupted intracellular metabolism, leading to altered transcriptional regulation and defective lineage differentiation, which provide a new pathway between mitochondrial biogenesis and epigenetic gene regulation indispensable for normal erythropoiesis.

Edited by: Guo Xinyu
Source: School of Life Sciences