Speaker: Shen Bo, National Institute of Biological Sciences, Beijing
16:00-17:00 p.m., November 21, 2023, GMT+8
B117, 2nd Research Complex, PKU
The bone marrow contains peripheral nerves that promote hematopoietic regeneration after irradiation or chemotherapy (myeloablation) but little is known about how this is regulated. We found that nerve growth factor (NGF) produced by Leptin Receptor-expressing(LepRt) stromal cells is required to maintain nerve fibers in adult bone marrow. In nerveless bone marrow, steady-state hematopoiesis was normal but hematopoietic and vascular regeneration were impaired after myeloablation. LepR+ cells, and the adipocytes they gave rise to, increased NGF production after myeloablation, promoting nerve sprouting in the bone marrow and hematopoietic and vascular regeneration. Nerves promoted regeneration by activating b2and b3 adrenergic receptor signaling in LepR+ cells, and potentially in adipocytes, increasing their production of multiple hematopoietic and vascular regeneration growth factors. Peripheral nerves and LepR+ cells thus promote bone marrow regeneration through a reciprocal relationship in which LepR+ cells sustain nerves by synthesizing NGF and nerves increase regeneration by promoting the production of growth factors by LepR+ cells.
School of Life Sciences, PKU