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[Lecture] A Transcription Factor Network Mediating Tumor Promotion and Tumor Suppression
Dec. 22, 2023

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Speaker: Prof. Robert N. Eisenman, Basic Sciences Division, Fred Hutchinson Cancer Research Center

Time: 11:00-12:00 a.m., December 22, 2023, GMT+8

Venue: Room 101, School of Life Sciences, PKU


The Eisenman lab is interested in the transcriptional regulation of normal and neoplastic cell growth and proliferation. We have focused for many years on the MYC gene family- an evolutionarily conserved group of genes encoding essential proteins deeply involved, on multiple levels, in normal cell functions. Moreover, the normal highly regulated expression of MYC is subverted and deregulated in a very wide range of both solid and hematopoietic cancers. MYC proteins are DNA-binding transcription factors of the bHLHZ class. Importantly MYC does not function alone but is one member of a larger network of bHLHZ proteins. My talk will describe this network and illustrate how functional interactions among network members are important in both the development and uppression of cancers.

Source: School of Life Sciences, PKU