Speaker: Prof. Robert N. Eisenman, Basic Sciences Division, Fred Hutchinson Cancer Research Center

Time: 11:00-12:00 a.m., December 22, 2023, GMT+8

Venue: Room 101, School of Life Sciences, PKU

Abstract: 

The Eisenman lab is interested in the transcriptional regulation of normal and neoplastic cell growth and proliferation. We have focused for many years on the MYC gene family- an evolutionarily conserved group of genes encoding essential proteins deeply involved, on multiple levels, in normal cell functions. Moreover, the normal highly regulated expression of MYC is subverted and deregulated in a very wide range of both solid and hematopoietic cancers. MYC proteins are DNA-binding transcription factors of the bHLHZ class. Importantly MYC does not function alone but is one member of a larger network of bHLHZ proteins. My talk will describe this network and illustrate how functional interactions among network members are important in both the development and uppression of cancers.

Source: School of Life Sciences, PKU