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[Lecture] New chemical biology tools for GPCRs
Jan. 25, 2024

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Speaker: Prof. Rob Leurs, Vrijie Universiteit Amsterdam, Netherlands

Time: 13:00-14:30 p.m., January 25, 2024, GMT+8

Venue: 101, Jinguang Life Science Building, PKU


G-protein coupled receptors (GPCRs) constitute one of the most important class of drug targets and responsible for around one third of current drugs in the pharmacy. At VU Amsterdam, we work for many years on the medicinal chemistry and chemical biology of various subfamilies of GPCRs, with a strong focus on both histamine and chemokine receptors. Over the years we have generated a number of exciting new chemical biology tools for the study of histamine and chemokine receptors, their ligands and their pharmacology. In this talk, I will describe the emergence of receptor structural biology and the development of new ligands for fluorescent labelling or photopharmacological approaches (photocaging and photoswitching). All these new tools allow the research community to develop new approaches to study histamine and chemokine receptors and their roles in (patho) physiology.

Source: School of Life Sciences, PKU