Speaker: Prof. Patrick Gilon, Research Direct of the FNRS Part-time Professor extraordinarie at UCL

Time: 09:30-10:30 a.m., April 20, 2024, GMT+8

Venue: Room 311, Jinguang Life Science Building, PKU 

Abstract: 

The endocrine pancreas plays a key role in blood glucose homeostasis. Insulin secreted by ß-cells is the main hypoglycemic hormone, while glucagon secreted by a-cells is hyperglycemic. The secretions of both hormones are controlled in an opposite way by glucose since the sugar stimulates insulin secretion while it inhibits glucagon release. The mechanisms by which glucose inhibits glucagon secretion are poorly understood. In particular, it is still unknown whether the glucagonostatic effect of glucose results from a direct action of the sugar on a-cells or an indirect action involving the release of an inhibitory paracrine factor from neighboring islet cells, such as insulin released by ß-cells or somatostatin released by -cells. In the presentation, I will present data from our lab discussing thе rоlе оf АТР-ѕеnѕіtіvе К+ (Кдтр) сhаnnеlѕ, somatostatin and ß-cells in the control of gluсаgоn ѕесrеtіоn bу gluсоѕе аnd КATР channel blockers (sulfonylureas).

Source: Academy for Advanced Interdisciplinary Studies, PKU