Speaker: Kai (Jack) Zhang, Prof. Yale University

Time: 13:30-15:00 p.m., July 9, 2024, GMT+8

Venue: B117, Research Complex #2 , PKU

Abstract: 

Mitochondria are essential for ATP production via oxidative phosphor-ylation, involving respiratory complexes within the inner membrane. Despite extensive in vitro studies, understanding their mechanisms in physiological environment is challenging due to loss of the native environment during purification. Here, we directly image porcine mitochondria by developing a high-resolution in-situ cryo-electron microscopy technique, which enabled us to determine near-atomic structures of various respiratory supercomplexes in the native membrane.

Source: College of Future Technology, PKU