Speaker: Jiandie Lin, Ph.D., Bradley M. Patten Collegiate Professor of Life Sciences, Professor of Cell & Developmental Biology, Research Professor, Life Sciences Institute Life Sciences Institute, University of Michigan

Time: 13:00-14:30 p.m., July 15, 2024, GMT+8

Venue: 3rd Floor, Lui Che-woo Building, PKU

Abstract: 

The mammalian liver comprises heterogeneous cell types that shape the tissue microenvironment in homeostasis and disease. Using single-cell transcriptomic analysis tools, we dissected the cellular landscape of liver microenvironment and the mechanisms that govern its reprogramming in disease. Our work identified TREM2+ macrophages as a novel disease driver and revealed an adipose-liver hormonal checkpoint in metabolic liver disease and liver cancer.

Source: School of Life Sciences, PKU